Morphine Induces Synchronous Oscillatory Discharges in the Rat Locus Coeruleus
نویسندگان
چکیده
منابع مشابه
Morphine induces synchronous oscillatory discharges in the rat locus coeruleus.
The noradrenergic locus coeruleus (LC) plays a role in opioid dependence and withdrawal. In the present study, using a multiple-electrode recording technique that allowed several LC neurons to be recorded simultaneously over long time periods, LC neuronal activities were recorded before and after intracerebroventricular injection of morphine (26 nmol) under halothane anesthesia. We found that m...
متن کاملMicroinjection of orexin-A into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
Introduction: It has been shown that orexin peptides have a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. However, LC neurons do not show withdrawalinduced hyperactivity in the brain slices from morphin...
متن کاملmicroinjection of orexin-a into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
introduction: it has been shown that orexin peptides have a role in opioid withdrawal behaviors. orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the locus coeruleus (lc). withdrawal syndrome is temporally associated with hyperactivity of lc neurons. however, lc neurons do not show withdrawalinduced hyperactivity in the brain slices from morphine-d...
متن کاملMicroinjection of orexin-A into the locus coeruleus area induces morphine withdrawal-like behaviors in morphine dependent rats
Introduction: It has been shown that orexin peptides have a role in opioid withdrawal behaviors. Orexin-expressing neurons that are present in the hypothalamic nuclei send dense projections to the Locus Coeruleus (LC). Withdrawal syndrome is temporally associated with hyperactivity of LC neurons. However, LC neurons do not show withdrawalinduced hyperactivity in the brain slices from morphine-d...
متن کاملChronic morphine treatment increases cyclic AMP-dependent protein kinase activity in the rat locus coeruleus.
We have studied a possible role for cyclic AMP-dependent protein kinase in mediating opiate addiction in the central nervous system by focusing on the rat locus coeruleus. This brain region is well suited for these studies because it is relatively homogeneous and because a wealth of electrophysiological and behavioral data indicate that it plays an important role in mediating the chronic effect...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2001
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.21-21-j0003.2001